Myoreval significantly upregulates SIRTUINS &
Nrf2 genes and significantly decreases risk factor
of CVD within first 180 days of therapy.

Cardiovascular diseases & coronary artery diseases

Cardiovascular disease (CVD) is more than just a medical term - it’s the no. 1 heart health threat worldwide.

Coronary artery disease (CAD) and its connection to Sirtuins and Nrf2

Coronary Artery Disease (CAD) isn’t just about blocked arteries-It is about what is happening at the cellular level.Two key players in heart health are sirtuins and Nrf2, which work together to protect heart from damage.

Sirtuins:The Longevity Gene

Sirtuins, helps to increase reverse cholesterol transport and promote HDL synthesis. Sirtuin activation also helps in boosting energy production in heart cells, they keep arteries healthy and slow down the buildup of harmful cholesterol plaques.

Nrf2:The Antinflammatory gene.

Nrf2 is the master switch for your body’s antioxidant defense. When activated it reduces oxidative stress and inflammation in arteries, protecting them from the damage that leads to CAD.

Why it matters?

When Sirtuins and Nrf2 are working properly, they act like a shield for heart-keeping arteries clear, reducing inflammation, and preventing plaque buildup. Boosting these pathway might be the next big thing in preventing and treating CAD.

Need of the hour is to Increase Reverse Cholesterol Transport (RCT), & is a novel strategy in plaque regression & coronary artery diseases.

Current research has well established relationship between circulating Sirtuins ng/ml & prognosis of chronic coronary syndrome, unstable angina & myocardial infarction.

Sirtuin genes which are nuclear in origin have been suggested to be a marker of cardiovascular risk & endothelial function.

Moreover low sirtuins is also been associated with decreased HDL & increased triglycerides (TG) & LDLs level leading to dyslipedemia & CAD.

Sirtuins are related with increased expression of master regulator of cholesterol metabolism (LXR- Liver X receptors) & master regulator of bile acid metabolism (FXR- Farnesoid X receptor).
Sirtuins are further known to upregulate excess cholesterol transporters in body ABCA1, ABCG1 & increasing expression of Apo-A1 promoting increased reverse cholesterol transport.